Picture frame vertebrae is a radiographic appearance seen in which disease?

Picture frame vertebrae is a radiographic appearance seen in which disease?

• A. Osteogenesis imperfecta
• B. Paget's disease
• C. Spondylitis
• D. Osteoarthritis

Answer: (B)

Picture frame vertebrae arise from the abnormal bone remodeling seen in Paget's disease. In this condition, rapid, disorganized turnover leads to thickened, sclerotic endplates and peripheral margins around the vertebral body, producing a radiographic frame around a relatively lucent central area. This pattern is classic for Paget’s disease (osteitis deformans) and helps distinguish it from other spinal conditions, which tend to show different features such as fragility changes in osteogenesis imperfecta, inflammatory or syndesmophyte patterns in spondylitis, or joint and facet changes in osteoarthritis.

Picture frame vertebrae arise from the abnormal bone remodeling seen in Paget's disease. In this condition, rapid, disorganized turnover leads to thickened, sclerotic endplates and peripheral margins around the vertebral body, producing a radiographic frame around a relatively lucent central area. This pattern is classic for Paget’s disease (osteitis deformans) and helps distinguish it from other spinal conditions, which tend to show different features such as fragility changes in osteogenesis imperfecta, inflammatory or syndesmophyte patterns in spondylitis, or joint and facet changes in osteoarthritis.